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From209US$ /night
Check-in
27Jan2026Select date
Check-out
28Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Waterfront Park
Great
8.7
9.3
/10
4.6
4.5
/5

21C Museum Hotel Louisville offers a unique blend of contemporary art and boutique accommodations. This 5-star hotel features 91 guest rooms, an on-site restaurant called Proof on Main, and over 9000 square feet of exhibition space. Guests can enjoy amenities such as free WiFi and a dedicated event staff.

Rooms & Amenities

The guest rooms at 21C Museum Hotel Louisville are designed with both comfort and artistic expression in mind. Each room includes a premium Bryte Restorative Sleep Bed, a flat-screen TV, and a mini-bar. Many rooms feature unique artworks and multi-purpose furniture designed by artists.

Dining & Events

Dining options include Proof on Main, which showcases Southern and Appalachian-inspired cuisine. The restaurant also hosts exclusive events such as the Fork & Bottle dinner series featuring regional spirits. Additionally, catering services are available for events held at the hotel.

Leisure & Attractions

Leisure facilities at 21C Museum Hotel include a fitness center and access to curated exhibitions in the hotel's galleries. Guests can explore nearby attractions such as the Louisville Slugger Museum & Bat Factory and the Muhammad Ali Center, located within a half mile. Events and performances often take place in association with the gallery exhibitions.

Business & Services

For business and events, 21C Museum Hotel offers four private galleries for meetings accommodating 10 to 60 guests. A dedicated event staff is available to assist with planning. Public transportation options include bus routes accessible within walking distance from the hotel.

“This hotel stands out for its immersive art experience, extending from the lobby to the unique guest rooms; the contemporary installations create a vibrant atmosphere. The on-site bourbon bar and proximity to Museum Row make it a notable choice in Louisville. It's a destination that engages and inspires.”
Hotel logo
Sophia TurnerEditorial Director at Spahotels
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Choose your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
315 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
335 sq. feet 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
660 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
500 sq. feet 
1 King-size bed
Shower
Coffee machine
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Price and Room Availability

Check availability and prices for your dates now!

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

At 21C Museum Hotel Louisville, dining transcends the ordinary with a modern American flair. Guests can delight in a vibrant, contemporary setting while indulging in regionally inspired dishes and attending unique culinary events that celebrate local spirits.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Modern setting featuring contemporary art and design, creating a lively dining atmosphere.
Key Offerings
Signature dishes incorporate local ingredients, and guests can enjoy special events like the Fork & Bottle dinner series, showcasing guest distillers and spirits. The annual Hog & Barrel dinner celebrates food and bourbon pairings, featuring Pappy Van Winkle.
Reservation
Recommended
Hours vary.

Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
600 ft
Museum
Muhammad Ali Center
1000 ft
Museum
Kentucky Science Center
500 ft
Museum
The Frazier History Museum
900 ft
Museum
Kentucky Museum of Art and Craft
300 ft
528 W Main St
Evan Williams Bourbon Experience
700 ft
Gallery
Flame Run Glass Studio and Gallery
1000 ft
500 W Main St
The Belvedere
900 ft
Night club
Jimmy Can't Dance
300 ft
801 W Main St
Michter's Fort Nelson Distillery
500 ft
Library
Sons of the American Revolution Genealogical Research Library
700 ft
120 N 10th St
Kentucky Peerless Distilling Co
1600 ft
401 W River Rd
Belle of Louisville Riverboats
2000 ft
Restaurants
Proof On Main
100 ft
702 West Main Street
Mussel & Burger Bar Downtown
200 ft
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
400 ft
614 W Main St
Atlantic No. 5
600 ft
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
600 ft
445 E Market St
Vincenzo's Italian Restaurant
1500 ft
150 S 5th St
Jockey Silks Bourbon Bar
1600 ft
140 N 4th St 2nd Floor - West Tower
Dish on Market
1600 ft
434 W Market St
Quiznos
1800 ft
223 S 5th St
Swizzle Dinner & Drinks
1800 ft
140 N Fourth St 25th Floor
Cafe Magnolia
2000 ft
140 N 4th St Galt House Hotel
Explore Louisville
Local Highlights Near 21C Museum Hotel
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Interactive science exhibits and IMAX experiences, perfect for families and science enthusiasts.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A cultural center dedicated to the life and legacy of Muhammad Ali, featuring engaging displays and events.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of the iconic baseball bat, offering tours and exhibits on the sport's history. Family-friendly and interactive.
The Frazier History Museum
The Frazier History Museum
4 minutes walking
A museum showcasing Kentucky's history through changing exhibits, artifacts, and engaging programs.
Waterfront Park
Waterfront Park
17 minutes walking
A scenic park ideal for picnics, outdoor sports, and walking paths along the Ohio River. Great for relaxation.
Biking along the Riverwalk
5 minutes driving
Rent a bike and enjoy a ride along the picturesque Riverwalk, which offers stunning views and fresh air.
Angel's Envy Distillery
Angel's Envy Distillery
19 minutes walking
Tours and tastings of premium bourbon are available, appealing to whiskey lovers. Reservations recommended.
Escape Room Louisville
10 minutes driving
Thrilling escape room experiences for friends and families looking for adventure and teamwork.
Proof On Main
Proof On Main
1 minute walking
A farm-to-table restaurant with a vibrant atmosphere, offering creative dishes and a diverse drink menu.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual dining specializing in gourmet burgers and mussel dishes, perfect for casual meals or gatherings.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
An upscale casual restaurant serving Southern cuisine with local ingredients; vegetarian options available.
Los Aztecas Mexican Restaurant
Los Aztecas Mexican Restaurant
3 minutes walking
Local favorite for authentic Mexican fare in a lively, colorful setting. Great for families or casual dining.
KFC Yum Center
KFC Yum Center
9 minutes walking
A premier venue for concerts and sporting events. Check the schedule for upcoming shows and games.
Fourth Street Live!
10 minutes walking
A vibrant entertainment district with live music, bars, and restaurants, perfect for nightlife and events.
Old Forester Distilling
Old Forester Distilling
15 minutes walking
A historic distillery offering guided tours, tastings, and insights into bourbon production; family-friendly.
Louisville Free Public Library
Louisville Free Public Library
15 minutes walking
A beautiful library with extensive collections, hosting events and programs perfect for all ages.

Getting around
City Centre
Louisville23 min  ·  1.2 mi
Airports
Louisville International Airport (SDF)18 min  ·  7.4 mi
Access exclusive early booking discounts.
Choose your spa escape today!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
FAQs
About 21C Museum Hotel Louisville
What are the check-in and check-out times at 21C Museum Hotel Louisville?
Check-in is at 16:00 and check-out is at 11:00.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is 10 km from Louisville International Airport.
What are the nearby attractions to 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), Kentucky Museum of Art & Craft (1 km), and Louisville Slugger Museum & Factory (0.5 km).
Is there on-site dining available at 21C Museum Hotel Louisville?
The hotel features Proof on Main, a restaurant offering unique southern cuisine.
What types of fitness facilities are available at 21C Museum Hotel Louisville?
Guests can access a 24-hour fitness center and a spa with a sauna and steam room.
What room amenities does 21C Museum Hotel Louisville provide?
Rooms feature free Wi-Fi, flat-screen TVs, minibars, coffee makers, and premium Bryte Restorative Sleep Beds.
What business services are offered at 21C Museum Hotel Louisville?
The hotel offers a business center, meeting rooms, and banquet facilities.
Are there any notable dining options close to 21C Museum Hotel Louisville?
Nearby dining options include Atlantic No. 5, Main Eatery, and Morton's The Steakhouse, all located within 0.5 km.
What are the spa services available at 21C Museum Hotel Louisville?
The spa offers services like full body massages, steam treatments, and yoga classes.
Is valet parking available at 21C Museum Hotel Louisville?
Valet parking is available at the hotel.
What accessibility features are available at 21C Museum Hotel Louisville?
The hotel provides wheelchair access and other features for guests with limited mobility.
What unique features does 21C Museum Hotel Louisville offer?
The hotel includes over 836.1 m² of exhibition space for contemporary art and immersive artist-designed guest rooms.

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Check-in
27Jan2026Select date
Check-out
28Jan2026Select date
Rooms and Guests2 Guests, 1 Room

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21C Museum Hotel Louisville Exterior photo

21C Museum Hotel Louisville

8.7
Great193 reviews
1.2 mi from center
188 US$
209 US$
per night
Mobile-only price